Deriving a genetic regulatory network from an optimization principle
Thomas R. Sokolovski, Thomas Gregor, William Bialek, Gašper Tkačik. Proceedings of the National Academy of Science 122 (2), e2402925121 (2025).
(more…)Posts Tagged ‘Drosophila’
Transcription factor clusters as information transfer agents
Rahul Munshi, Jia Ling, Sergey Ryabichko, Eric F. Wieschaus, Thomas Gregor. Science Advances 11 (1), DOI: 10.1126/sciadv.adp3251 (2025).
(more…)Scale invariance in early embryonic development
Milos Nikolić, Victoria Antonetti, Feng Liu F, Gentian Muhaxheri, Mariela D Petkova, Martin Scheeler, Eric M Smith, William Bialek, Thomas Gregor. Proceedings of the National Academy of Science (USA) 121 (46) e2403265121, (2024).
(more…)Finding the last bits of positional information
Lauren McGough, Helena Casademunt, Miloš Nikolić, Zoe Aridor, Mariela D. Petkova, Thomas Gregor, William Bialek. PRX Life 2 (1), 013016 (2024)
Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels
Netta Haroush, Michal Levo, Eric Wieschaus, Thomas Gregor. Developmental Cell 58 (23), 2789-2801.e5 (2023).
(more…)Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome
David B. Brückner, Hongtao Chen, Lev Barinov, Benjamin Zoller, Thomas Gregor. Science 380, 1357-1362 (2023).
Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies
Lukas Voortman, Caitlin Anderson, Elizabeth Urban, Luorongxin Yuan, Sang Tran, Alexandra Neuhaus-Follini, Josh Derrick, Thomas Gregor, and Robert J. Johnston, Jr. Developmental Cell. 57(15), 1817–1832.E5 (2022).
Latent space of a small genetic network: Geometry of dynamics and information
Rabea Seyboldt, Juliette Lavoie, Adrien Henry, Jules Vanaret, Mariela D. Petkova, Thomas Gregor, and Paul François. Proceedings of the National Academy of Science 119 (26): e2113651119 (2022).
Transcriptional coupling of distant regulatory genes in living embryos
Michal Levo, João Raimundo, Xin Yang Bing, Zachary Sisco, Philippe J. Batut, Sergey Ryabichko, Thomas Gregor & Michael S. Levine (2022). Nature 605, 754–760 (2022).
Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation
Anand P. Singh, Ping Wu, Sergey Ryabichko, Joao Raimundo, Michael Swan, Eric Wieschaus,
Thomas Gregor, and Jared E. Toettcher (2022). Cell Reports 38, 110543.
Trading bits in the readout from a genetic network
Marianne Bauer, Mariela D Petkova, Thomas Gregor, Eric F Wieschaus, William Bialek (2021). Proceedings of the National Academy of Science 118 (46): e2109011118.
The many bits of positional information
Gašper Tkačik and Thomas Gregor. Development 148: dev176065 (2021) (more…)
Using RNA Tags for Multicolor Live Imaging of Chromatin Loci and Transcription in Drosophila Embryos
Chen H and Gregor T. In: Heinlein M. (eds) RNA Tagging. Methods in Molecular Biology, vol 2166. Humana, New York, NY (2020). (more…)
Optimal decoding of cellular identities in a genetic network
Mariela D. Petkova, Gasper Tkacik, William Bialek, Eric F. Wieschaus, and Thomas Gregor. Cell 176(4), 844–855 (2019). (more…)
Diverse spatial expression patterns emerge from unified kinetics of transcriptional bursting
Benjamin Zoller, Shawn C. Little, and Thomas Gregor. Cell 175(3), 835–847 (2018). (more…)
Dynamic interplay between enhancer-promoter topology and gene activity
Hongtao Chen, Michal Levo, Lev Barinov, Miki Fujioka, James B. Jaynes and Thomas Gregor. Nature Genetics 50, 1296–1303 (2018). (more…)
Single mRNA Molecule Detection in Drosophila
Shawn C Little and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)
Live Imaging of mRNA Synthesis in Drosophila
Hernan G Garcia and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)
Only accessible information is useful: insights from gradient-mediated patterning
Mikhail Tikhonov, Shawn C. Little, and Thomas Gregor. Roy. Soc. Open Sci. 2: 150486 (2015). (more…)
Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
Jacques Bothma, Hernan Garcia, Samuel Ng, Michael W. Perry, Thomas Gregor, and Michael S. Levine. eLife 2015; 4:e07956 (2015). (more…)