Fly wing vein patterns have spatial reproducibility of a single cell
Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor. J. Roy. Soc. Interface 11 (97): 20140443 (2014).
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Posts Tagged ‘Drosophila’
Lots of November Press for TGLab
“Seeing the Pattern”
Nature Reviews Genetics (PDF)
“Measuring Transcription to Follow Embryo Development”
BioTechniques News Highlight
“Scientist to watch: Thomas Gregor – Biological Quantifier”
The Scientist
“Development: Lights, Camera, Action — The Drosophila Embryo Goes Live!”
Current Biology Dispatch by Bothma and Levine (PDF)
“Nature – the IT wizard”
Nautilus Magazine
Maternal origins of developmental reproducibility
Mariela D. Petkova, Shawn C. Little, Feng Liu, and Thomas Gregor. Current Biology 24 (11): 1283–1288 (2014).
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Morphogenesis at criticality
Dmitry Krotov, Julien O. Dubuis, Thomas Gregor, and William Bialek. PNAS 111 (10): 3683–3688 (2014).
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Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
Hernan G. Garcia, Mikhail Tikhonov, Albert Lin and Thomas Gregor. Current Biology 23, 2140–2145 (2013).
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Precision and reproducibility of macroscopic developmental patterns
Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor (2013). arXiv.org:1309.6273 [q-bio.TO].
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Positional information, in bits
Julien O. Dubuis, Gasper Tkacik, Eric F. Wieschaus, Thomas Gregor and William Bialek, PNAS 110, 16301-16308 (2013).
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Precise developmental gene expression arises from globally stochastic transcriptional activity
Shawn C. Little, Mikhail Tikhonov and Thomas Gregor, Cell 154, 789–800 (2013).
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Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
Feng Liu, Alexander H. Morrison and Thomas Gregor, PNAS 110: 6724–6729 (2013).
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Accurate measurements of dynamics and reproducibility in small genetic networks
Julien O. Dubuis, Reba Samanta and Thomas Gregor, Molecular Systems Biology 9: 639 (2013).
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Quantifying the Bicoid morphogen gradient in living fly embryos
Alexander H. Morrison, Martin Scheeler Julien O. Dubuis and Thomas Gregor, Cold Spring Harb Protoc. 2012(4): 398-406 (2012).
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Researchers Develop Improved Method to Visualize Biologic Molecules
PLoS Press Release for our first paper on mRNA quantification in whole embryos.
“How are biologic molecules arranged inside the embryo so that embryonic development occurs reliably every time? Princeton researchers, led by Thomas Gregor, an assistant professor of physics and the Lewis-Sigler Institute for Integrative Genomics, and Shawn Little, a postdoctoral fellow in the laboratory of Professor Eric Wieschaus in the Department of Molecular Biology, have developed a new method to better understand how an embryo’s basic molecular makeup helps ensure that the embryo’s development occurs reliably every time. The results of this research into the fruit fly Drosophila introduce a method for making precise measurements of biologic units (so-called mRNA molecules) that play a key role in development. The findings are published in the March 1st issue of in the online, open access journal PLoS Biology.”
The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA.
Shawn Little, Gašper Tkačik, Thomas Kneeland, Eric Wieschaus and Thomas Gregor, PLoS Biology 9(3): e1000596 (2011).
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Postdoctoral position available
Even if people can always apply by simply sending me an email, for the next two months I am actually officially looking to fill a postdoctoral position, primarily to work on the fly embryogenesis project. It would make some administrators at Princeton really happy if you could go through this site and follow instructions from there. Please be sure to clearly state why you would be interested in joining the lab.
The role of input noise in transcriptional regulation.
G. Tkačik, T. Gregor, W. Bialek, PLoS One 3, e2774 (2008).
Diffusion and scaling during early embryonic pattern formation.
T. Gregor, W. Bialek, R. R. deRuyter van Steveninck, D. W. Tank, E. F. Wieschaus, PNAS 102, 18403-18407 (2005).