Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome
David B. Brückner, Hongtao Chen, Lev Barinov, Benjamin Zoller, Thomas Gregor. Science 380, 1357-1362 (2023).
Posts Tagged ‘transcription’
Eukaryotic gene regulation at equilibrium, or non?
Benjamin Zoller, Thomas Gregor, and Gasper Tkacik. Current Opinion in System Biology 31: 100435 (2022).
Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies
Lukas Voortman, Caitlin Anderson, Elizabeth Urban, Luorongxin Yuan, Sang Tran, Alexandra Neuhaus-Follini, Josh Derrick, Thomas Gregor, and Robert J. Johnston, Jr. Developmental Cell. 57(15), 1817–1832.E5 (2022).
Transcriptional coupling of distant regulatory genes in living embryos
Michal Levo, João Raimundo, Xin Yang Bing, Zachary Sisco, Philippe J. Batut, Sergey Ryabichko, Thomas Gregor & Michael S. Levine (2022). Nature 605, 754–760 (2022).
The Impact of Space and Time on the Functional Output of the Genome
Marcello Nollmann, Isma Bennabi, Markus Götz, and Thomas Gregor (2021). Cold Spring Harb Perspect Biol.: a040378. doi: 10.1101/cshperspect.a040378.
(more…)Using RNA Tags for Multicolor Live Imaging of Chromatin Loci and Transcription in Drosophila Embryos
Chen H and Gregor T. In: Heinlein M. (eds) RNA Tagging. Methods in Molecular Biology, vol 2166. Humana, New York, NY (2020). (more…)
Diverse spatial expression patterns emerge from unified kinetics of transcriptional bursting
Benjamin Zoller, Shawn C. Little, and Thomas Gregor. Cell 175(3), 835–847 (2018). (more…)
Dynamic interplay between enhancer-promoter topology and gene activity
Hongtao Chen, Michal Levo, Lev Barinov, Miki Fujioka, James B. Jaynes and Thomas Gregor. Nature Genetics 50, 1296–1303 (2018). (more…)
Single mRNA Molecule Detection in Drosophila
Shawn C Little and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)
Live Imaging of mRNA Synthesis in Drosophila
Hernan G Garcia and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)
Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
Jacques Bothma, Hernan Garcia, Samuel Ng, Michael W. Perry, Thomas Gregor, and Michael S. Levine. eLife 2015; 4:e07956 (2015). (more…)
The embryo as a laboratory: quantifying transcription in Drosophila
Thomas Gregor, Hernan G. Garcia, Shawn C. Little. Trends in Genetics 30 (8): 364–375 (2014).
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Dynamic Regulation of Eve Stripe 2 Expression Reveals Transcriptional Bursts in Living Drosophila Embryos
Jacques P. Bothma, Hernan G. Garcia, Emilia Esposito, Gavin Schlissel, Thomas Gregor, Michael S. Levine. PNAS 111 (29): 10598–10603 (2014).
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Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
Hernan G. Garcia, Mikhail Tikhonov, Albert Lin and Thomas Gregor. Current Biology 23, 2140–2145 (2013).
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Precise developmental gene expression arises from globally stochastic transcriptional activity
Shawn C. Little, Mikhail Tikhonov and Thomas Gregor, Cell 154, 789–800 (2013).
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