Deriving a genetic regulatory network from an optimization principle
Thomas R. Sokolovski, Thomas Gregor, William Bialek, Gašper Tkačik. Proceedings of the National Academy of Science 122 (2), e2402925121 (2025).
(more…)Publications
Transcription factor clusters as information transfer agents
Rahul Munshi, Jia Ling, Sergey Ryabichko, Eric F. Wieschaus, Thomas Gregor. Science Advances 11 (1), DOI: 10.1126/sciadv.adp3251 (2025).
(more…)Scale invariance in early embryonic development
Milos Nikolić, Victoria Antonetti, Feng Liu F, Gentian Muhaxheri, Mariela D Petkova, Martin Scheeler, Eric M Smith, William Bialek, Thomas Gregor. Proceedings of the National Academy of Science (USA) 121 (46) e2403265121, (2024).
(more…)Finding the last bits of positional information
Lauren McGough, Helena Casademunt, Miloš Nikolić, Zoe Aridor, Mariela D. Petkova, Thomas Gregor, William Bialek. PRX Life 2 (1), 013016 (2024)
Precise and scalable self-organization in mammalian pseudo-embryos
Mélody Merle, Leah Friedman, Corinne Chureau, Armin Shoushtarizadeh, Thomas Gregor.
Nature Structural & Molecular Biology 31, 896–902, doi: 10.1038/s41594-024-01251-4 (2024)
Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels
Netta Haroush, Michal Levo, Eric Wieschaus, Thomas Gregor. Developmental Cell 58 (23), 2789-2801.e5 (2023).
(more…)Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome
David B. Brückner, Hongtao Chen, Lev Barinov, Benjamin Zoller, Thomas Gregor. Science 380, 1357-1362 (2023).
Growth produces coordination trade-offs in Trichoplax adhaerens, an animal lacking a central nervous system
Mircea R. Davidescu, Pavel Romanczuk, Thomas Gregor, Iain D. Cousin. Proc Natl Acad Sci (USA) 120 (11) e2206163120 (2023).
(more…)Structured foraging of soil predators unveils functional responses to bacterial defenses
Fernando W. Rossine, Gabriel Vercelli, Corina Tarnita, and Thomas Gregor. Proceedings of the National Academy of Science (USA) 119(52): e2210995119 (2022).
(more…)Eukaryotic gene regulation at equilibrium, or non?
Benjamin Zoller, Thomas Gregor, and Gasper Tkacik. Current Opinion in System Biology 31: 100435 (2022).
Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies
Lukas Voortman, Caitlin Anderson, Elizabeth Urban, Luorongxin Yuan, Sang Tran, Alexandra Neuhaus-Follini, Josh Derrick, Thomas Gregor, and Robert J. Johnston, Jr. Developmental Cell. 57(15), 1817–1832.E5 (2022).
Latent space of a small genetic network: Geometry of dynamics and information
Rabea Seyboldt, Juliette Lavoie, Adrien Henry, Jules Vanaret, Mariela D. Petkova, Thomas Gregor, and Paul François. Proceedings of the National Academy of Science 119 (26): e2113651119 (2022).
Transcriptional coupling of distant regulatory genes in living embryos
Michal Levo, João Raimundo, Xin Yang Bing, Zachary Sisco, Philippe J. Batut, Sergey Ryabichko, Thomas Gregor & Michael S. Levine (2022). Nature 605, 754–760 (2022).
Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation
Anand P. Singh, Ping Wu, Sergey Ryabichko, Joao Raimundo, Michael Swan, Eric Wieschaus,
Thomas Gregor, and Jared E. Toettcher (2022). Cell Reports 38, 110543.
The Impact of Space and Time on the Functional Output of the Genome
Marcello Nollmann, Isma Bennabi, Markus Götz, and Thomas Gregor (2021). Cold Spring Harb Perspect Biol.: a040378. doi: 10.1101/cshperspect.a040378.
(more…)Trading bits in the readout from a genetic network
Marianne Bauer, Mariela D Petkova, Thomas Gregor, Eric F Wieschaus, William Bialek (2021). Proceedings of the National Academy of Science 118 (46): e2109011118.
The many bits of positional information
Gašper Tkačik and Thomas Gregor. Development 148: dev176065 (2021) (more…)
Using RNA Tags for Multicolor Live Imaging of Chromatin Loci and Transcription in Drosophila Embryos
Chen H and Gregor T. In: Heinlein M. (eds) RNA Tagging. Methods in Molecular Biology, vol 2166. Humana, New York, NY (2020). (more…)
Eco-evolutionary significance of “loners”
Fernando W. Rossine, Ricardo Martinez-Garcia, Allyson E. Sgro, Thomas Gregor, Corina E. Tarnita. Eco-evolutionary significance of “loners”. PLoS Biol 18(3): e3000642 (2020). (more…)
Optimal decoding of cellular identities in a genetic network
Mariela D. Petkova, Gasper Tkacik, William Bialek, Eric F. Wieschaus, and Thomas Gregor. Cell 176(4), 844–855 (2019). (more…)