Finding the last bits of positional information
Lauren McGough, Helena Casademunt, Miloš Nikolić, Zoe Aridor, Mariela D. Petkova, Thomas Gregor, William Bialek.
PRX Life 2 (1), 013016 (2024)
Posts Tagged ‘Bicoid’
Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation
Anand P. Singh, Ping Wu, Sergey Ryabichko, Joao Raimundo, Michael Swan, Eric Wieschaus,
Thomas Gregor, and Jared E. Toettcher (2022). Cell Reports 38, 110543.
The many bits of positional information
Gašper Tkačik and Thomas Gregor. Development 148: dev176065 (2021) (more…)
Maternal origins of developmental reproducibility
Mariela D. Petkova, Shawn C. Little, Feng Liu, and Thomas Gregor. Current Biology 24 (11): 1283–1288 (2014).
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Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
Feng Liu, Alexander H. Morrison and Thomas Gregor, PNAS 110: 6724–6729 (2013).
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Quantifying the Bicoid morphogen gradient in living fly embryos
Alexander H. Morrison, Martin Scheeler Julien O. Dubuis and Thomas Gregor, Cold Spring Harb Protoc. 2012(4): 398-406 (2012).
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Researchers Develop Improved Method to Visualize Biologic Molecules
PLoS Press Release for our first paper on mRNA quantification in whole embryos.
“How are biologic molecules arranged inside the embryo so that embryonic development occurs reliably every time? Princeton researchers, led by Thomas Gregor, an assistant professor of physics and the Lewis-Sigler Institute for Integrative Genomics, and Shawn Little, a postdoctoral fellow in the laboratory of Professor Eric Wieschaus in the Department of Molecular Biology, have developed a new method to better understand how an embryo’s basic molecular makeup helps ensure that the embryo’s development occurs reliably every time. The results of this research into the fruit fly Drosophila introduce a method for making precise measurements of biologic units (so-called mRNA molecules) that play a key role in development. The findings are published in the March 1st issue of in the online, open access journal PLoS Biology.”
The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA.
Shawn Little, Gašper Tkačik, Thomas Kneeland, Eric Wieschaus and Thomas Gregor, PLoS Biology 9(3): e1000596 (2011).
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Can we fit all of the data?
W. Bialek, T. Gregor, D.W. Tank, E.F. Wieschaus, Cell 132, 17-18 (2008).
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Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos.
T. Gregor, A. P. McGregor, E. F. Wieschaus, Dev. Biol. 316, 350-358 (2008).
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Probing the limits to positional information.
T. Gregor, E. F. Wieschaus, D. W. Tank, W. Bialek, Cell 130, 153-164 (2007).
Stability and nuclear dynamics of the Bicoid morphogen gradient.
T. Gregor, E. F. Wieschaus, A. P. McGregor, W. Bialek, D. W. Tank, Cell 130, 141-152 (2007).
Diffusion and scaling during early embryonic pattern formation.
T. Gregor, W. Bialek, R. R. deRuyter van Steveninck, D. W. Tank, E. F. Wieschaus, PNAS 102, 18403-18407 (2005).