Posts Tagged ‘Drosophila’

Optimal decoding of cellular identities in a genetic network

Mariela D. Petkova MD, Gasper Tkacik, William Bialek, Eric F. Wieschaus, and Thomas Gregor. Cell 176(4), 844–855 (2019). (more…)

Diverse spatial expression patterns emerge from unified kinetics of transcriptional bursting

Benjamin Zoller, Shawn C. Little, and Thomas Gregor. Cell 175(3), 835–847 (2018). (more…)

Dynamic interplay between enhancer-promoter topology and gene activity

Hongtao Chen, Michal Levo, Lev Barinov, Miki Fujioka, James B. Jaynes and Thomas Gregor. Nature Genetics 50, 1296–1303 (2018). (more…)

Single mRNA Molecule Detection in Drosophila

Shawn C Little and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)

Live Imaging of mRNA Synthesis in Drosophila

Hernan G Garcia and Thomas Gregor. In: Gaspar I. (eds) RNA Detection. Methods in Molecular Biology, vol 1649. Humana Press, New York, NY (2018) (more…)

Only accessible information is useful: insights from gradient-mediated patterning

Mikhail Tikhonov, Shawn C. Little, and Thomas Gregor. Roy. Soc. Open Sci. 2: 150486 (2015). (more…)

Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo

Jacques Bothma, Hernan Garcia, Samuel Ng, Michael W. Perry, Thomas Gregor, and Michael S. Levine. eLife 2015; 4:e07956 (2015). (more…)

Positional information, positional error, and read-out precision in morphogenesis: a mathematical framework

Gasper Tkačik, Julien O. Dubuis, Mariela D. Petkova, and Thomas Gregor. Genetics 199 (1): 39–59 (2015).  (more…)

The embryo as a laboratory: quantifying transcription in Drosophila

Thomas Gregor, Hernan G. Garcia, Shawn C. Little. Trends in Genetics 30 (8): 364–375 (2014).
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Dynamic Regulation of Eve Stripe 2 Expression Reveals Transcriptional Bursts in Living Drosophila Embryos

Jacques P. Bothma, Hernan G. Garcia, Emilia Esposito, Gavin Schlissel, Thomas Gregor, Michael S. Levine. PNAS 111 (29): 10598–10603 (2014).
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Fly wing vein patterns have spatial reproducibility of a single cell

Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor.  J. Roy. Soc. Interface 11 (97): 20140443 (2014).
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Lots of November Press for TGLab

“Seeing the Pattern”
Nature Reviews Genetics (PDF)

“Measuring Transcription to Follow Embryo Development”
BioTechniques News Highlight

“Scientist to watch: Thomas Gregor – Biological Quantifier”
The Scientist

“Development: Lights, Camera, Action — The Drosophila Embryo Goes Live!”
Current Biology Dispatch by Bothma and Levine (PDF)

“Nature – the IT wizard”
Nautilus Magazine

Maternal origins of developmental reproducibility

Mariela D. Petkova, Shawn C. Little, Feng Liu, and Thomas Gregor. Current Biology 24 (11): 1283–1288 (2014).
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Morphogenesis at criticality

Dmitry Krotov, Julien O. Dubuis, Thomas Gregor, and William Bialek. PNAS 111 (10): 3683–3688 (2014).
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Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning

Hernan G. Garcia, Mikhail Tikhonov, Albert Lin and Thomas Gregor. Current Biology 23, 2140–2145 (2013).
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Precision and reproducibility of macroscopic developmental patterns

Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor (2013).  arXiv.org:1309.6273 [q-bio.TO].
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Positional information, in bits

Julien O. Dubuis, Gasper Tkacik, Eric F. Wieschaus, Thomas Gregor and William Bialek, PNAS 110, 16301-16308 (2013).
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Precise developmental gene expression arises from globally stochastic transcriptional activity

Shawn C. Little, Mikhail Tikhonov and Thomas Gregor, Cell 154, 789–800 (2013).
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Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network

Feng Liu, Alexander H. Morrison and Thomas Gregor, PNAS 110: 6724–6729 (2013).
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Accurate measurements of dynamics and reproducibility in small genetic networks

Julien O. Dubuis, Reba Samanta and Thomas Gregor, Molecular Systems Biology 9: 639 (2013).
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