Publications

Only accessible information is useful: insights from gradient-mediated patterning

Mikhail Tikhonov, Shawn C. Little, and Thomas Gregor. Roy. Soc. Open Sci. 2: 150486 (2015). (more…)

Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo

Jacques Bothma, Hernan Garcia, Samuel Ng, Michael W. Perry, Thomas Gregor, and Michael S. Levine. eLife 2015; 4:e07956 (2015). (more…)

Modeling oscillations and spiral waves in Dictyostelium populations

Javad Noorbakhsh, David J. Schwab, Allyson E. Sgro, Thomas Gregor, and Pankaj Mehta. Physical Review E 91: 062711 (2015).  (more…)

From Intracellular Signaling to Population Oscillations: Bridging Size and Time Scales in Collective Behavior

Allyson E. Sgro, David J. Schwab, Javad Noorbakhsh, Troy Mestler, Pankaj Mehta, and Thomas Gregor. Molecular Systems Biology 11: 799 (2015).  (more…)

Positional information, positional error, and read-out precision in morphogenesis: a mathematical framework

Gasper Tkačik, Julien O. Dubuis, Mariela D. Petkova, and Thomas Gregor. Genetics 199 (1): 39–59 (2015).  (more…)

The embryo as a laboratory: quantifying transcription in Drosophila

Thomas Gregor, Hernan G. Garcia, Shawn C. Little. Trends in Genetics 30 (8): 364–375 (2014).
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Dynamic Regulation of Eve Stripe 2 Expression Reveals Transcriptional Bursts in Living Drosophila Embryos

Jacques P. Bothma, Hernan G. Garcia, Emilia Esposito, Gavin Schlissel, Thomas Gregor, Michael S. Levine. PNAS 111 (29): 10598–10603 (2014).
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Fly wing vein patterns have spatial reproducibility of a single cell

Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor.  J. Roy. Soc. Interface 11 (97): 20140443 (2014).
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Maternal origins of developmental reproducibility

Mariela D. Petkova, Shawn C. Little, Feng Liu, and Thomas Gregor. Current Biology 24 (11): 1283–1288 (2014).
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Morphogenesis at criticality

Dmitry Krotov, Julien O. Dubuis, Thomas Gregor, and William Bialek. PNAS 111 (10): 3683–3688 (2014).
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Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning

Hernan G. Garcia, Mikhail Tikhonov, Albert Lin and Thomas Gregor. Current Biology 23, 2140–2145 (2013).
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Precision and reproducibility of macroscopic developmental patterns

Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt, and Thomas Gregor (2013).  arXiv.org:1309.6273 [q-bio.TO].
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Positional information, in bits

Julien O. Dubuis, Gasper Tkacik, Eric F. Wieschaus, Thomas Gregor and William Bialek, PNAS 110, 16301-16308 (2013).
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Precise developmental gene expression arises from globally stochastic transcriptional activity

Shawn C. Little, Mikhail Tikhonov and Thomas Gregor, Cell 154, 789–800 (2013).
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Sorting sloppy Sonic

Shawn C. Little and Thomas Gregor, Cell 153, 509-510 (2013).
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Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network

Feng Liu, Alexander H. Morrison and Thomas Gregor, PNAS 110: 6724–6729 (2013).
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Accurate measurements of dynamics and reproducibility in small genetic networks

Julien O. Dubuis, Reba Samanta and Thomas Gregor, Molecular Systems Biology 9: 639 (2013).
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Quantifying the Bicoid morphogen gradient in living fly embryos

Alexander H. Morrison, Martin Scheeler Julien O. Dubuis and Thomas GregorCold Spring Harb Protoc. 2012(4): 398-406 (2012).
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The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA.

Shawn Little, Gašper Tkačik, Thomas Kneeland, Eric Wieschaus and Thomas Gregor, PLoS Biology 9(3): e1000596 (2011).
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Approaching the molecular origins of collective dynamics in oscillating cell populations

Pankaj Mehta and Thomas Gregor, Current Opinion in Genetics & Development 20, 574-80 (2010).
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